In vivo diagnosis of nasopharyngeal carcinoma using contact rhinoscopy
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AbstractObjectives: To evaluate the potential use of con. tact endoscopy for the diagnosis of nasopharyngeal carcinoma (NPC). Study Design. Prospective study to examine the nasopharynx of 30 patients with nasopharyngeal carcinoma and 18 subjects with normal nasopharynx in a clinic setting using contact rhino-scopes (Karl Storz, Tuttlingen, Germany, 7215 AA, 0 degrees and 7215 BA, 30 degrees; 23 cm long, 4 mm. in diameter). Methods. The superficial cells of the normal nasopharynx and the nasopharyngeal tumors were stained with 1% methylene blue and examined with contact rhinoscopes at high magnifications (x60 and x150). The areas under examination were then biopsied. The contact endoscopic images were compared with the corresponding hematoxylin and eosin-stained histologic sections of the biopsied tissues. Results: Sixty-six procedures were performed in 48 patients. The images of normal pseudostratified ciliated epithelium and squamous epithelium were readily recognized by contact endoscopy in all subjects with normal nasopharynx (10 men and 8 women; mean age, 51.9 y). Twenty-six of 30 patients with NPC (86.6%;, 18 men and 8 women; mean age, 50.6 y) were successfully examined by contact endoscopy under local anesthesia. In these 26 patients, two patterns of malignant cells were identified with contact endoscopy. The patterns of contact endoscopic images corresponded well with the histologic findings. Conclusion: Contact endoscopy is an accurate and reliable office-based procedure, which allows for in-vivo diagnosis of nasopharyngeal carcinoma.
All Author(s) ListPak MW, To KF, Leung SF, van Hasselt CA
Journal nameLaryngoscope
Volume Number111
Issue Number8
Pages1453 - 1458
LanguagesEnglish-United Kingdom
Keywordscontact endoscope; in-situ histology; nasopharyngeal carcinoma; nasopharynx
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Otorhinolaryngology; OTORHINOLARYNGOLOGY; Research & Experimental Medicine

Last updated on 2021-26-02 at 01:56