In vivo diagnosis of nasopharyngeal carcinoma using contact rhinoscopy
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摘要Objectives: To evaluate the potential use of con. tact endoscopy for the diagnosis of nasopharyngeal carcinoma (NPC). Study Design. Prospective study to examine the nasopharynx of 30 patients with nasopharyngeal carcinoma and 18 subjects with normal nasopharynx in a clinic setting using contact rhino-scopes (Karl Storz, Tuttlingen, Germany, 7215 AA, 0 degrees and 7215 BA, 30 degrees; 23 cm long, 4 mm. in diameter). Methods. The superficial cells of the normal nasopharynx and the nasopharyngeal tumors were stained with 1% methylene blue and examined with contact rhinoscopes at high magnifications (x60 and x150). The areas under examination were then biopsied. The contact endoscopic images were compared with the corresponding hematoxylin and eosin-stained histologic sections of the biopsied tissues. Results: Sixty-six procedures were performed in 48 patients. The images of normal pseudostratified ciliated epithelium and squamous epithelium were readily recognized by contact endoscopy in all subjects with normal nasopharynx (10 men and 8 women; mean age, 51.9 y). Twenty-six of 30 patients with NPC (86.6%;, 18 men and 8 women; mean age, 50.6 y) were successfully examined by contact endoscopy under local anesthesia. In these 26 patients, two patterns of malignant cells were identified with contact endoscopy. The patterns of contact endoscopic images corresponded well with the histologic findings. Conclusion: Contact endoscopy is an accurate and reliable office-based procedure, which allows for in-vivo diagnosis of nasopharyngeal carcinoma.
著者Pak MW, To KF, Leung SF, van Hasselt CA
期刊名稱Laryngoscope
出版年份2001
月份8
日期1
卷號111
期次8
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次1453 - 1458
國際標準期刊號0023-852X
電子國際標準期刊號1531-4995
語言英式英語
關鍵詞contact endoscope; in-situ histology; nasopharyngeal carcinoma; nasopharynx
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Otorhinolaryngology; OTORHINOLARYNGOLOGY; Research & Experimental Medicine

上次更新時間 2021-13-01 於 23:38