Induction of apoptosis by a ribosome-inactivating protein from Agrostemma githago is associated with down-regulation of anti-apoptotic bcl-2 protein expression
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摘要Agrostin is a type 1 ribosome-inactivating protein (RIP) isolated from the seeds of Agrostemma githago. (3)[H]-thymidine incorporation in human leukemic HL-60 cells was significantly reduced after incubation with agrostin showing that the RIP was inhibitory on the cell proliferation. Results from flow cytometric studies illustrated that apoptosis was induced by agrostin, which was associated with activation of endonucleases acid DNA fragmentation of the leukemic cells. Anti-apoptotic bcl-2 protein level was also reduced by agrostin showing that the associated apoptotic pathway might involve down-regulation of the intracellular bcl-2 protein level.
著者Chiu LCM, Ooi VEC, Sun SSM
期刊名稱International Journal of Oncology
出版年份2001
月份7
日期1
卷號19
期次1
出版社PROFESSOR D A SPANDIDOS
頁次137 - 141
國際標準期刊號1019-6439
電子國際標準期刊號1791-2423
語言英式英語
關鍵詞agrostin; anti-proliferation; apoptosis; bcl-2; flow cytometry
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-13-01 於 00:58