Induction of apoptosis by a ribosome-inactivating protein from Agrostemma githago is associated with down-regulation of anti-apoptotic bcl-2 protein expression
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AbstractAgrostin is a type 1 ribosome-inactivating protein (RIP) isolated from the seeds of Agrostemma githago. (3)[H]-thymidine incorporation in human leukemic HL-60 cells was significantly reduced after incubation with agrostin showing that the RIP was inhibitory on the cell proliferation. Results from flow cytometric studies illustrated that apoptosis was induced by agrostin, which was associated with activation of endonucleases acid DNA fragmentation of the leukemic cells. Anti-apoptotic bcl-2 protein level was also reduced by agrostin showing that the associated apoptotic pathway might involve down-regulation of the intracellular bcl-2 protein level.
All Author(s) ListChiu LCM, Ooi VEC, Sun SSM
Journal nameInternational Journal of Oncology
Year2001
Month7
Day1
Volume Number19
Issue Number1
PublisherPROFESSOR D A SPANDIDOS
Pages137 - 141
ISSN1019-6439
eISSN1791-2423
LanguagesEnglish-United Kingdom
Keywordsagrostin; anti-proliferation; apoptosis; bcl-2; flow cytometry
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-12-08 at 01:21