Risk factors for cataract in Chinese patients with type 2 diabetes: evidence for the influence of the aldose reductase gene
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AbstractThere is evidence that the development of retinopathy in type 2 diabetes is associated with a microsatellite polymorphism at 5' of the aldose reductase gene. The study examined whether cataract was associated with clinical/metabolic factors and/or the microsatellite polymorphism using a cohort of consecutively recruited Hong Kong Chinese patients with type 2 diabetes (n = 567). Amongst these patients, 157 (28%) had cataract. The patients with cataract were older in age and age at diagnosis and had longer diabetes duration than those without cataract (all at p < 0.01). They also had higher systolic blood pressure (P < 0.01), HbA(1c) (p < 0.05) and fasting plasma glucose levels (p < 0.01; all with adjustment for the significance). Moreover, we found that the patients with cataract over-presented the microsatellite allele Z (23 vs. 30%, p < 0.01) and its genotypes (Z,Z + Z,non-Z; 38 vs. 50%, p < 0.01), but under-presented the allele Z - 4 (8.3 vs 4.8%, p < 0.05) and its genotypes (Z - 4, Z - 4 + Z - 4,non-Z - 4; 16 vs. 10%, p < 0.05). Using multiple logistic regression analysis (R-2 = 0.25, P < 0.01), we found that the presence of cataract was correlated positively with age, but inversely with the presence of allele Z - 4. In conclusion, our data indicate that the occurrence of cataract is common in the Chinese type 2 diabetes population, with age and the aldose reductase gene as important determinants.
All Author(s) ListLee SC, Wang Y, Ko GTC, Ma RCW, Critchley JAJH, Cockram CS, Chan JCN
Journal nameClinical Genetics
Volume Number59
Issue Number5
Pages356 - 359
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesGenetics & Heredity; GENETICS & HEREDITY

Last updated on 2020-10-09 at 00:56