Action of glucocorticoids to antagonise cisplatin-induced acute and delayed emesis in the ferret
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摘要Cisplatin 5 mg/kg, i.p, induced an acute (day 1) and delayed (days 2 and 3) emetic response in the ferret that was used to investigate the potential anti-emetic activity of several glucocorticoids. Betamethasone (0.3-3 mg/kg, i.p.) reduced the emesis occurring during the initial 0-24-h period by 71.1-99.5% (P < 0.05). The action of methylprednisolone (1.0-10.0 mg/kg, i.p.) and hydrocortisone (1.0-30.0 mg/kg, i.p.) could not be assessed because the controls exhibited weak emetic responses and dexamethasone produced a non-significant 64.0% reduction at 0.3 mg/kg (P > 0.05). However, all glucocorticoids dose-dependently reduced retching + vomiting during the subsequent 24-56-h period. The rank order of anti-emetic potency was betamethasone (ID80 < 0.3 mg/kg) 2 dexamethasone (ID80 = 0.32 mg/kg)> methylprednisolone (ID80 = 0.66 mg/kg) much greater than hydrocortisone (ID80 > 30 mg/kg). Dexamethasone was ineffective to antagonise the retching + vomiting response during the 24-56-h period when the administration was delayed until 24 h post-cisplatin injection. None of the glucocorticoids reduced the retching + vomiting response occurring during the 56-72-h period. In conclusion, the rank order of anti-emetic potency suggests that inflammation, or mediators of inflammation, contribute to the retching + vomiting response induced by cisplatin. (C) 2001 Published by Elsevier Science B.V.
著者Sam TSW, Chan SW, Rudd JA, Yeung JHK
期刊名稱European Journal of Pharmacology
出版年份2001
月份4
日期13
卷號417
期次3
出版社ELSEVIER SCIENCE BV
頁次231 - 237
國際標準期刊號0014-2999
電子國際標準期刊號1879-0712
語言英式英語
關鍵詞cisplatin; emesis; glucocorticoid
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2021-06-06 於 01:43