Transfusion of peripheral blood stem cells from donor homozygous for a shared HLA-haplotype - Avoiding fatal transfusion-associated graft-versus-host disease while preserving anti-leukemic effect
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AbstractBackground Fatal transfusion-associated graft-versus-host disease was observed in immunocompetent patients transfused with blood from donors homozygous for a shared haplotype with the recipient (the P-F1 barrier), We tested whether it was possible to carry out successful transplantation in a patient with relapsed acute myeloid leukemia, using peripheral blood stem cells from his HLA-homozygous brother (HLA A2, B46, DRB1 901) who shared a haplotype with the patient (HLA A2, B46,75, DRB1 901,12).
All Author(s) ListWong R, Lau FY, Chui CH, Tsang KS, Chik KW, Li CK, Cheng G
Journal nameTransplantation
Volume Number71
Issue Number3
Pages487 - 490
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesImmunology; IMMUNOLOGY; Surgery; SURGERY; Transplantation; TRANSPLANTATION

Last updated on 2021-14-01 at 00:43