A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs
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AbstractThe aqueous and methanol extracts of twenty herbs traditionally used in Chinese medicine were screened for anti-HIV-1 integrase activity in a non-radioactive ELISA-based HIV-1 integrase assay. The screening was performed at an herb extract concentration of 50 mug/ml. It was found that most of the aqueous and methanol herb extracts could elicit strong inhibition of HIV-1 integrase activity. The inhibition was most likely due to tannins or polyphenolics in the herb extracts. In most of the herb extracts, 40-80% of the anti-HIV-1 integrase activity could be removed after passing through a minicolumn of polyamide resin. After removal of polyphenolic compounds, the methanol extract of Paeonia suffruticosa still exerted potent inhibition of HIV-1 integrase (EC50=15 mug/ml) and the aqueous extract of Prunella vulgaris caused moderate inhibition (EC50=45 mug/ml). The results support the view that herbs represent a rich source of anti-HIV compounds. (C) 2001 Elsevier Science Inc. All rights reserved.
All Author(s) ListAu TK, Lam TL, Ng TB, Fong WP, Wan DCC
Journal nameLife Sciences
Volume Number68
Issue Number14
Pages1687 - 1694
LanguagesEnglish-United Kingdom
KeywordsChinese medicinal herbs; HIV-1 integrase; polyphenolic compounds; tannins
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

Last updated on 2021-10-05 at 03:36