A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs
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AbstractThe aqueous and methanol extracts of twenty herbs traditionally used in Chinese medicine were screened for anti-HIV-1 integrase activity in a non-radioactive ELISA-based HIV-1 integrase assay. The screening was performed at an herb extract concentration of 50 mug/ml. It was found that most of the aqueous and methanol herb extracts could elicit strong inhibition of HIV-1 integrase activity. The inhibition was most likely due to tannins or polyphenolics in the herb extracts. In most of the herb extracts, 40-80% of the anti-HIV-1 integrase activity could be removed after passing through a minicolumn of polyamide resin. After removal of polyphenolic compounds, the methanol extract of Paeonia suffruticosa still exerted potent inhibition of HIV-1 integrase (EC50=15 mug/ml) and the aqueous extract of Prunella vulgaris caused moderate inhibition (EC50=45 mug/ml). The results support the view that herbs represent a rich source of anti-HIV compounds. (C) 2001 Elsevier Science Inc. All rights reserved.
All Author(s) ListAu TK, Lam TL, Ng TB, Fong WP, Wan DCC
Journal nameLife Sciences
Year2001
Month2
Day23
Volume Number68
Issue Number14
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Pages1687 - 1694
ISSN0024-3205
eISSN1879-0631
LanguagesEnglish-United Kingdom
KeywordsChinese medicinal herbs; HIV-1 integrase; polyphenolic compounds; tannins
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

Last updated on 2020-30-05 at 00:27