Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. (C) 2001 Cancer Research Campaign.
著者Leung WK, To KF, Ng YP, Lee TL, Lau JYW, Chan FKL, Ng EKW, Chung SCS, Sung J
期刊名稱British Journal of Cancer
出版年份2001
月份2
日期2
卷號84
期次3
出版社CHURCHILL LIVINGSTONE
頁次335 - 339
國際標準期刊號0007-0920
電子國際標準期刊號1532-1827
語言英式英語
關鍵詞cyclo-oxygenase-2; gastric cancer; mutation; p53 gene
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-22-01 於 01:07