Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
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AbstractWild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. (C) 2001 Cancer Research Campaign.
All Author(s) ListLeung WK, To KF, Ng YP, Lee TL, Lau JYW, Chan FKL, Ng EKW, Chung SCS, Sung J
Journal nameBritish Journal of Cancer
Volume Number84
Issue Number3
Pages335 - 339
LanguagesEnglish-United Kingdom
Keywordscyclo-oxygenase-2; gastric cancer; mutation; p53 gene
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2021-12-09 at 00:21