Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells
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摘要Green tea catechins (GTCs) including (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG) and (-)-epicatechin (EC) were shown to suppress cell growth and induce apoptosis in various cell systems in addition to their chemo-preventive effect. In this study, except EC which was inactive, green tea extract (TE) and other 3 GTCs were found to suppress the growth and induce apoptosis in human prostate cancer DU145 cells largely through an increase in reactive oxygen species formation and mitochondrial depolarization. The conclusion was supported by the fact that the profiles for different GTCs in growth suppression, apoptosis induction, ROS formation and mitochondrial depolarization are in a similar order, i.e. ECG > EGCG > EGC > EC. Although the molecular mechanisms are still not clear, apoptosis induced by GTCs is not related to the members of BCL-2 family as EGCG did not alter the expression of BCL-2, BCL-X(L) and BAD in DU145 cells. (C) 2001 Elsevier Science Inc. All rights reserved.
著者Chung LY, Cheung TC, Kong SK, Fung KP, Choy YM, Chen ZY, Kwok TT
期刊名稱Life Sciences
出版年份2001
月份1
日期26
卷號68
期次10
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次1207 - 1214
國際標準期刊號0024-3205
電子國際標準期刊號1879-0631
語言英式英語
關鍵詞apoptosis; DU145 cells; free radicals; green tea catechins
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

上次更新時間 2020-03-08 於 06:06