Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells
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AbstractGreen tea catechins (GTCs) including (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG) and (-)-epicatechin (EC) were shown to suppress cell growth and induce apoptosis in various cell systems in addition to their chemo-preventive effect. In this study, except EC which was inactive, green tea extract (TE) and other 3 GTCs were found to suppress the growth and induce apoptosis in human prostate cancer DU145 cells largely through an increase in reactive oxygen species formation and mitochondrial depolarization. The conclusion was supported by the fact that the profiles for different GTCs in growth suppression, apoptosis induction, ROS formation and mitochondrial depolarization are in a similar order, i.e. ECG > EGCG > EGC > EC. Although the molecular mechanisms are still not clear, apoptosis induced by GTCs is not related to the members of BCL-2 family as EGCG did not alter the expression of BCL-2, BCL-X(L) and BAD in DU145 cells. (C) 2001 Elsevier Science Inc. All rights reserved.
All Author(s) ListChung LY, Cheung TC, Kong SK, Fung KP, Choy YM, Chen ZY, Kwok TT
Journal nameLife Sciences
Year2001
Month1
Day26
Volume Number68
Issue Number10
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Pages1207 - 1214
ISSN0024-3205
eISSN1879-0631
LanguagesEnglish-United Kingdom
Keywordsapoptosis; DU145 cells; free radicals; green tea catechins
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

Last updated on 2020-02-07 at 05:15