Renin-angiotensin system gene polymorphisms, blood pressure, dyslipidemia, and diabetes in Hong Kong Chinese - A significant association of the ACE insertion/deletion polymorphism with type 2 diabetes
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AbstractOBJECTIVE- In Chinese populations, hypertension is common and is a major risk factor fur cerebrovascular and coronary heart disease, particularly when associated with diabetes. The clustering of these disorders and dyslipidemia and obesity is termed the metabolic syndrome and is increasing in prevalence in the populations of modernizing Asian nations. The renin-angiotensin system (RAS) helps maintain blood pressure and salt homeostasis and may play a role in the pathogenesis of aspects of the metabolic syndrome. We investigated three RAS gene polymorphisms-the ACE insertion/deletion (I/D), angiotensinogen (AGT) M235T, and angiotensin II type 1 receptor (AT(1)R) A1166C polymorphisms-for a possible role in modulating these disorders in 853 Chinese subjects with varying components of the metabolic symdrome.
All Author(s) ListThomas GN, Tomlinson B, Chan JCN, Sanderson JE, Cockram CS, Critchley JAJH
Journal nameDiabetes Care
Volume Number24
Issue Number2
Pages356 - 361
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesEndocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

Last updated on 2021-27-09 at 06:24