Clearance of TT virus after allogeneic bone marrow transplantation
Publication in refereed journal

Times Cited
Web of Science4WOS source URL (as at 20/09/2021) Click here for the latest count
Altmetrics Information

Other information
AbstractA 10-year-old girl with thalassemia underwent bone marrow transplantation. Before transplantation, she had persistent TT virus (TTV) DNAemia for at least 18 months. Interestingly, the viral DNAemia was cleared soon after transplant and remained undetectable at the latest follow-up at 28 months. The early clearance of TTV that had occurred before engraftment or initiation of any antiviral therapy, together with the absence of TTV DNA from the results of the liver biopsy performed before transplantation, led us to hypothesize that the hematologic compartment could have been the site for viral persistence. Thus, the conditioning regimen may have depleted the hemic cells and the hematologically compartmentalized TTV. The potential of hemic tropism of TTV and its role in hematologic diseases need to be considered.
All Author(s) ListChan PKS, Chik KW, To KF, Li CK, Hui M, Shing MMK, Yuen PMP, Tam JS, Cheng AF
Journal nameJournal of Pediatric Hematology/Oncology
Volume Number23
Issue Number1
Pages57 - 58
LanguagesEnglish-United Kingdom
Keywordsbone marrow transplant; hematology; persistence; thalassemia; tropism; TTV
Web of Science Subject CategoriesHematology; HEMATOLOGY; Oncology; ONCOLOGY; Pediatrics; PEDIATRICS

Last updated on 2021-21-09 at 00:35