Generalized low areal and volumetric bone mineral density in adolescent idiopathic scoliosis
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摘要Adolescent idiopathic scoliosis (AIS) maybe associated with generalized low bone mineral status. The bone mineral density (BMD) of 75 girls of 12-14 years of age and diagnosed as having AIS were compared with 94 age-matched female control subjects. Areal I)MD (aBMD) of the lumbar spine (L2-L4) and the bilateral proximal femur were measured using -energy X-ray absorptiometry (DEXA), and volumetric BMD (vBMD) of the nondominant distal radius and bilateral distal tibias was measured with peripheral quantitative computer tomography (pQCT), Relevant anthropometric parameters and the severity of the spinal deformity (Cobb's angle) also were evaluated and correlated with the BMD measurements, Results revealed the presence of a generalized lower bone mineral status in AIS patients, Detailed analysis showed that the aBMD and vBMD measured at the bilateral lower extremities were significantly lower in AIS patients when compared with the same in the normal controls. The most significant effect was seen in the trabecular BMD (tBMD) of the distal tibias, Of all the AIS girls, 38% of the aBMD and 36% of the vBMD were below -1 SD of the normal. BMD was found to correlate better with "years since menarche" (YSM) than with chronological age. When the BMD was evaluated for the 3 YSM groups, aBMD of the proximal femur and tBMD off distal tibias were found to be significantly lower in the AIS patients. Neither the aBMD nor the vBMD of AIS patients was found to be associated with the severity of spinal deformity. In addition, anthropometric measurements showed significantly longer arm span and lower extremities in the AIS girls. We concluded that the AIS girls had generalized lower aBMDs and vBMDs.
著者Cheng JCY, Qin L, Cheung CSK, Sher AHL, Lee KM, Ng SWE, Guo X
會議名稱1st International Conference on Childrens Bone Health
會議開始日01.01.1999
會議地點MAASTRICHT
期刊名稱Journal of Bone and Mineral Research
出版年份2000
月份8
日期1
卷號15
期次8
出版社AMER SOC BONE & MINERAL RES
頁次1587 - 1595
國際標準期刊號0884-0431
電子國際標準期刊號1523-4681
語言英式英語
關鍵詞adolescent idiopathic scoliosis; bone mineral density; dual-energy X-ray absorptiometry; osteopenia; peripheral quantitative computer tomography
Web of Science 學科類別Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

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