Nutritional value of Ganoderma extract and assessment of its genotoxicity and anti-genotoxicity using comet assays of mouse lymphocytes
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AbstractThe nutritive composition of a hot aqueous extract of wild Ganoderma fruit bodies was determined. This extract was assessed for cytotoxicity and in vivo genotoxicity by both acute and subchronic exposure of mice (given by mouth at a dose equivalent to extract of 220 g fresh Ganoderma fruit body/kg body weight). To test any alleged protection against mutagens by Ganoderma treatments, the mice were injected intraperitoneally with the radiomimetic mutagen ethyl methanesulfonate (EMS), and after 24 hr of treatment their lymphocytes were examined using the comet assay. Ganoderma extract consisted of Folin-positive, material (68.9% of dry weight), but protein comprised only 7.3% of dry weight. Glucose accounted fur 11.1% and metals 10.2% of dry weight (K, Mg and Ca being the major components with Cc (often touted as being of value in sales literature for Ganoderma preparations) having the fifth highest metal concentration at 489 mu g/g). In comparison to rodent chow, Ganoderma extract was a modest dietary supplement, No evidence was found for genotoxic chromosomal breakage nor cytotoxic effects by Ganoderma extract in the mouse, nor did it protect against the effects of ethyl methanesulfonate. We found no support in this study for the extract having any value in protecting against the test mutagen. (C) 2000 Elsevier Science Ltd. All rights reserved.
All Author(s) ListChiu SW, Wang ZM, Leung TM, Moore D
Journal nameFood and Chemical Toxicology
Year2000
Month2
Day1
Volume Number38
Issue Number2-3
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Pages173 - 178
ISSN0278-6915
eISSN1873-6351
LanguagesEnglish-United Kingdom
Keywordscomet assay; Ganoderma; genotoxicity; lingzhi; nutraceutical; single-cell gel electrophoresis
Web of Science Subject CategoriesFood Science & Technology; FOOD SCIENCE & TECHNOLOGY; Toxicology; TOXICOLOGY

Last updated on 2021-21-02 at 00:19