Modulation of the Ca2+-activated Cl- channel by 14-3-3 epsilon
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摘要We have previously reported an association of 14-3-3 epsilon isoform with calmodulin. Using the voltage-clamp technique, the present study investigated the potential role of 14-3-3 in modulating the Ca2+-activated Cl- channel (CaCC) endogenously expressed in Xenopus oocytes. Injection of 14-3-3 epsilon antisense oligodeoxynucleotides resulted in potentiation of the ionomycin-induced Cl- current, while 14-3-3 peptide and calmodulin inhibitor, W13, suppressed the antisense-potentiated current. The data suggest that 14-3-3 epsilon plays an inhibitory role in modulating the CaCC by interacting with the calmodulin-dependent pathway. The potential role of 14-3-3 epsilon in other tissues and its therapeutic potential for cystic fibrosis are discussed. (C) 2000 Academic Press.
著者Chan HC, Wu WL, So SC, Chung YW, Tsang LL, Wang XF, Yan YC, Luk SCW, Siu SS, Tsui SKW, Fung KP, Lee CY, Waye MMY
期刊名稱Biochemical and Biophysical Research Communications
出版年份2000
月份4
日期13
卷號270
期次2
出版社ACADEMIC PRESS INC
頁次581 - 587
國際標準期刊號0006-291X
電子國際標準期刊號1090-2104
語言英式英語
關鍵詞14.3.3; calcium activated chloride channel; calmodulin; human; Xenopus
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS

上次更新時間 2020-02-08 於 04:23