Polarized distribution of NHE1 and NHE2 in the rat epididymis
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摘要Previous studies from our laboratory have provided evidence that the rat epididymis utilizes the Na+/H+ exchanger to transport acid and base. The present study was undertaken to use immunohistochemistry for investigating the localization (apical versus basolateral) and distribution of NHE1 and NHE2 proteins along intact rat epididymis. Both proteins were found to be exclusively localized within the epithelium. Immunoreactivity for NHE1 was detected on the basolateral surface, whereas NHE2 immunoreactivity was detected on the apical side of the epithelium. Interestingly, NHE1 was found along the entire length of the epididymal tubule whereas NHE2 was absent in the initial segment but present in the caput, corpus, and cauda regions. These results, when interpreted along with those of previous functional studies, may suggest that the apical NHE2 is involved in Na+ reabsorption and the basolateral NHE1 in HCO3- secretion in the rat epididymis.
著者Chew SBC, Leung GPH, Leung PY, Tse CM, Wong PYD
期刊名稱Biology of Reproduction
出版年份2000
月份3
日期1
卷號62
期次3
出版社SOC STUDY REPRODUCTION
頁次755 - 758
國際標準期刊號0006-3363
電子國際標準期刊號1529-7268
語言英式英語
Web of Science 學科類別Reproductive Biology; REPRODUCTIVE BIOLOGY

上次更新時間 2021-22-02 於 00:17