Proton magnetic resonance spectroscopy of late delayed radiation-induced injury of the brain
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摘要We prospectively evaluated metabolite changes in late delayed radiation-induced injury to the temporal lobes on proton (H-1) magnetic resonance spectroscopy (MRS) in 34 patients. Morphologically more severe injury on imaging tended to have lower N-acetyl aspartate (NAA)/creatine (Cr) and NAA/choline (Cho) ratios, A significantly higher Cho/Cr ratio was found in the most severe grade of cerebral necrosis, in which lactate might be present. The progressive decrease in NAA with increasing severity reflected neuronal loss at different stages of fate delayed radiation-induced brain injury, The absence of Cho elevation in mild and moderate lesions did not suggest demyelination or glial hyperplasia as an etiologic mechanism of late delayed radiation-induced brain injury. The association of severe morphologic lesions with elevated lactate suggests ischemia as the underlying mechanism for severe lesions,H-1 MRS may provide metabolite information conducive to the understanding of the pathophysiology of late radiation-induced brain injury. (C) 1999 Wiley-Liss, Inc.
著者Chan YL, Yeung DKW, Leung SF, Cao G
期刊名稱Journal of Magnetic Resonance Imaging
出版年份1999
月份8
日期1
卷號10
期次2
出版社JOHN WILEY & SONS INC
頁次130 - 137
國際標準期刊號1053-1807
電子國際標準期刊號1522-2586
語言英式英語
關鍵詞choline; CNS; H-1-MRS; lactate; N-acetyl aspartate; nasopharyngeal carcinoma; radiation injury; radiation necrosis; spectroscopy; temporal lobe
Web of Science 學科類別Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

上次更新時間 2021-21-01 於 01:56