Proton magnetic resonance spectroscopy of late delayed radiation-induced injury of the brain
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AbstractWe prospectively evaluated metabolite changes in late delayed radiation-induced injury to the temporal lobes on proton (H-1) magnetic resonance spectroscopy (MRS) in 34 patients. Morphologically more severe injury on imaging tended to have lower N-acetyl aspartate (NAA)/creatine (Cr) and NAA/choline (Cho) ratios, A significantly higher Cho/Cr ratio was found in the most severe grade of cerebral necrosis, in which lactate might be present. The progressive decrease in NAA with increasing severity reflected neuronal loss at different stages of fate delayed radiation-induced brain injury, The absence of Cho elevation in mild and moderate lesions did not suggest demyelination or glial hyperplasia as an etiologic mechanism of late delayed radiation-induced brain injury. The association of severe morphologic lesions with elevated lactate suggests ischemia as the underlying mechanism for severe lesions,H-1 MRS may provide metabolite information conducive to the understanding of the pathophysiology of late radiation-induced brain injury. (C) 1999 Wiley-Liss, Inc.
All Author(s) ListChan YL, Yeung DKW, Leung SF, Cao G
Journal nameJournal of Magnetic Resonance Imaging
Volume Number10
Issue Number2
Pages130 - 137
LanguagesEnglish-United Kingdom
Keywordscholine; CNS; H-1-MRS; lactate; N-acetyl aspartate; nasopharyngeal carcinoma; radiation injury; radiation necrosis; spectroscopy; temporal lobe
Web of Science Subject CategoriesRadiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Last updated on 2021-05-03 at 00:42