Acute renal failure in a patient with Rosai-Dorfman disease
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AbstractAcute renal failure developed in a 57-year-old woman who had Rosai-Dorfman disease diagnosed 1 year previously on a cervical lymph node. Organ imaging showed diffuse masses infiltrating both kidneys. The renal biopsy showed a lymphoplasmacytic and histiocytic process extensively replacing the parenchyma, which is in keeping with Rosai-Dorfman disease of the kidneys. However, the typical lymphophagocytic cells were lacking. This case illustrates that diagnosis of Rosai-Dorfman disease in renal biopsy can be very difficult, requiring both exclusion of many benign and malignant lesions and a high index of suspicion for this condition. In particular, lymphoma was excluded based on the mixed polyclonal composition of inflammatory cells and the absence of atypical lymphoid proliferation. The renal function partially recovered after a course of therapy combining VP-16 (etoposide) and dexamethasone and remained stable over 4-year follow-up. This report emphasizes the importance of early diagnosis and intervention to safeguard renal function in extensive Rosai-Dorfman disease. (C) 1999 by the National Kidney Foundation, Inc.
All Author(s) ListLai FMM, To KF, Szeto CC, Wang AYM, Ahuja AT, Choi PCL, Leung CB, Kew J, Li PKT
Journal nameAmerican Journal of Kidney Diseases
Volume Number34
Issue Number3
Pagesart. no. - e12
LanguagesEnglish-United Kingdom
Keywordsacute renal failure; emperipolesis; lymphadenopathy; pseudolymphoma; renal biopsy; Rosai-Dorfman disease
Web of Science Subject CategoriesUrology & Nephrology; UROLOGY & NEPHROLOGY

Last updated on 2021-21-01 at 01:56