Lack of allelic association of dopamine D4 receptor gene polymorphisms with Parkinson's disease in a Chinese population
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摘要Parkinson's disease (PD) is a neurodegenerative disease caused by a multitude of environmental, neurochemical, and genetic factors. The gene for human dopamine D4 receptor (DRD4) has been considered as a plausible candidate for the pathogenesis of PD. Different dopamine D4 receptor allelic forms have variable affinity toward certain neuroleptics such as clozapine, suggesting a role for dopamine D4 receptors in neurologic disorders. To test the hypothesis that the DRD4 polymorphism is associated with the susceptibility to Parkinson's disease, we have examined differences in allele frequencies of different DRD4 polymorphisms in 101 Chinese patients with PD and in 105 age-matched control subjects in Hong Kong. The DRD4 gene was analyzed by a non-radioactive polymerase chain reaction-based Southern hybridization with chemiluminescence detection. The number of polymorphic 48 base pair tandem repeats in exon 3 was identified in each study subject. The DRD4 alleles with high frequencies in the control subjects are 4-repeat allele (72.4%), 2-repeat allele (21.4%), and 7-repeat allele (3.8%) which accounted for over 97% of the total alleles in the elderly Chinese population. The most prevalent genotype in the control subjects is the 4/4 (47.6%), followed by 4/2 (38.6), 4/7 (7.6%), and 2/2 (3.0%). None of the variable number tandem repeat polymorphism showed evidence for genetic association with Parkinson's disease.
著者Wan DCC, Law LK, Ip DTM, Cheung WT, Ho WKK, Tsim KWK, Kay R, Woo J, Pang CP
期刊名稱Movement Disorders
出版年份1999
月份3
日期1
卷號14
期次2
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次225 - 229
國際標準期刊號0885-3185
電子國際標準期刊號1531-8257
語言英式英語
關鍵詞Chinese; dopamine D4 receptor polymorphism; Parkinson's disease
Web of Science 學科類別Clinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology

上次更新時間 2020-15-10 於 01:32