Inhibition of glucose uptake and suppression of glucose transporter 1 mRNA expression in L929 cells by tumour necrosis factor-alpha
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摘要Recombinant human tumour necrosis factor-alpha (rhTNF-alpha) arrested the growth and suppressed glucose uptake of mouse fibrosarcoma L929 cells in vitro. When the cells were treated with rhTNF-alpha for 24 hours, the mRNA level of glucose transporter 1 (GLUT 1), which is the only GLUT found to be present in L929 cells in our study, was suppressed in a dose-dependent manner. Since the growth of tumour cells depends mainly on glucose catabolism, our findings may indicate that rhTNF-alpha inhibits L929 cells growth by lowering the glucose transport through suppression of GLUT 1 mRNA expression in the cells. (C) 1999 Elsevier Science Inc.
著者Liong E, Kong SK, Au KK, Li JY, Xu GY, Lee YL, Kwok TT, Choy YM, Lee CY, Fung KP
期刊名稱Life Sciences
出版年份1999
月份9
日期3
卷號65
期次15
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次PL215 - PL220
國際標準期刊號0024-3205
電子國際標準期刊號1879-0631
語言英式英語
關鍵詞glucose transporter; L929 cell; TNF-alpha
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

上次更新時間 2020-02-08 於 04:10