Inhibition of glucose transporter gene expression by antisense nucleic acids in HL-60 leukemia cells
Publication in refereed journal


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摘要Glucose is the basic source of energy for mammalian cells. The energy-independent transport of glucose down its concentration gradient is mediated by the facilitative glucose transporter family (GLUT). It has long been recognised that glucose transporter genes are overexpressed in many human cancer cells, to help provide extra energy for the rapid growth of cancer cells. In the present study, antisense oligonucleotides and plasmid-derived antisense RNA against GLUT-1 gene were synthesized and transfected into human leukemia HL-60 cells to investigate the effect of these antisense nucleic acids on tumour growth. Our results show that antisense nucleic acids inhibited the proliferation of HL-60 cells by 50-60% and the mRNA expression of GLUT-1 gene was suppressed as detected by Northern hybridization.
著者Chan JYW, Kong SK, Choy YM, Lee CY, Fung KP
期刊名稱Life Sciences
出版年份1999
月份5
日期28
卷號65
期次1
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次63 - 70
國際標準期刊號0024-3205
電子國際標準期刊號1879-0631
語言英式英語
關鍵詞antisense nucleic acid; glucose transporter; HL-60 cells
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

上次更新時間 2020-11-08 於 04:22