Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1
Publication in refereed journal


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摘要Four-and-a-half LIM domain proteins (FHL) possess four tandem repeats of LIM domain and an extra zinc finger. FHL family LIM proteins are unique when compared with other LIM-only proteins because they possess an odd number of zinc fingers. In this study, the tissue distribution and chromosomal mapping of skeletal muscle LIM protein FHL3 were reported When the FHL3 cDNA probe was used to hybridize with poly-(A) RNA of various human tissues, a very strong signal was detected in skeletal muscle, and virtually no signal could be detected in heart, brain, placenta, lung, liver kidney and pancreas. Using radiation hybrid technique, FHL3 gene was mapped to the distal end of the short arm of chromosome 1 (123.26 cR from the top of the Chr1 linkage group) and this region (near 1p34) is related to several human malignancies.
著者Lee SMY, Tsui SKW, Chan KK, Kotaka M, Li HY, Chim SSC, Waye MMY, Fung KP, Lee CY
期刊名稱Somatic Cell and Molecular Genetics
出版年份1998
月份5
日期1
卷號24
期次3
出版社KLUWER ACADEMIC/PLENUM PUBL
頁次197 - 202
國際標準期刊號0740-7750
語言英式英語
Web of Science 學科類別Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity

上次更新時間 2020-19-11 於 00:59