Effect of basic fibroblast growth factor (bFGF) in tendon healing using an alginate gel as the delivery system
Refereed conference paper presented and published in conference proceedings


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摘要This study investigated the effect of basic fibroblast growth factor (bFGF) in healing patellar tendon through a delivery system of alginate gel. Male SD rats were divided into five groups. A gap wound sized 1x4mm was created in the mid patellar tendon. In the growth factor groups, a slab of alginate gel, loaded with either 0.4, 0.8 or 1.0 mu g of bFGF, was implanted into the wound at the time of injury. Alginate gel only was used in the vehicle control while no treatment was performed in the natural healing control. Tendons were harvested at 1 week post-injury. Three in each group were stained with proliferating cells and collagen type III. The rest were assessed for ultimate stress, total collagen and pyridinoline. One microgram of bFGF stimulated the expression of nuclear cyclin and collagen III, but induced a 36% decrease in pyridinoline and 59% in ultimate stress comparing with the control (p<0.05). The current study demonstrated that bFGF stimulated both cellular and extracellular changes. Besides, alginate was a valid model of delivering bioactive factors into the wound. However, it impaired the tensile properties that may be associated to a decrease in pyridinoline crosslink and an increase in immature type III collagen.
著者Chan BP, Fu SC, Qin L, Chan KM
會議名稱10th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
會議開始日29.10.1998
會議完結日01.11.1998
會議地點HONG KONG
會議國家/地區中國
期刊名稱PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6
出版年份1998
月份1
日期1
卷號20
出版社IEEE
頁次2884 - 2885
國際標準書號0-7803-5164-9
國際標準期刊號1094-687X
語言英式英語
關鍵詞alginate; basic fibroblast growth factor (bFGF); healing; patellar tendon
Web of Science 學科類別Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; Clinical Neurology; Engineering; Engineering, Biomedical; Medical Informatics; Medical Laboratory Technology; Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging

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