Effect of basic fibroblast growth factor (bFGF) in tendon healing using an alginate gel as the delivery system
Refereed conference paper presented and published in conference proceedings


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AbstractThis study investigated the effect of basic fibroblast growth factor (bFGF) in healing patellar tendon through a delivery system of alginate gel. Male SD rats were divided into five groups. A gap wound sized 1x4mm was created in the mid patellar tendon. In the growth factor groups, a slab of alginate gel, loaded with either 0.4, 0.8 or 1.0 mu g of bFGF, was implanted into the wound at the time of injury. Alginate gel only was used in the vehicle control while no treatment was performed in the natural healing control. Tendons were harvested at 1 week post-injury. Three in each group were stained with proliferating cells and collagen type III. The rest were assessed for ultimate stress, total collagen and pyridinoline. One microgram of bFGF stimulated the expression of nuclear cyclin and collagen III, but induced a 36% decrease in pyridinoline and 59% in ultimate stress comparing with the control (p<0.05). The current study demonstrated that bFGF stimulated both cellular and extracellular changes. Besides, alginate was a valid model of delivering bioactive factors into the wound. However, it impaired the tensile properties that may be associated to a decrease in pyridinoline crosslink and an increase in immature type III collagen.
All Author(s) ListChan BP, Fu SC, Qin L, Chan KM
Name of Conference10th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
Start Date of Conference29/10/1998
End Date of Conference01/11/1998
Place of ConferenceHONG KONG
Country/Region of ConferenceChina
Journal namePROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6
Year1998
Month1
Day1
Volume Number20
PublisherIEEE
Pages2884 - 2885
ISBN0-7803-5164-9
ISSN1094-687X
LanguagesEnglish-United Kingdom
Keywordsalginate; basic fibroblast growth factor (bFGF); healing; patellar tendon
Web of Science Subject CategoriesCardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; Clinical Neurology; Engineering; Engineering, Biomedical; Medical Informatics; Medical Laboratory Technology; Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging

Last updated on 2021-15-10 at 00:19