An in vivo study of the rat patellar tendon healing - Histological, biochemical and biomechanical aspects
Refereed conference paper presented and published in conference proceedings


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摘要Patellar tendon central one third is removed during anterior cruciate ligament reconstruction. The current study investigates an in vivo model of patellar tendon healing, histologically, biochemically and biomechanically. The histological appearance and the ultimate stress of the central one third patellar tendon were studied over time. The specimens were also analyzed for collagen and non-reducible crosslinks, as measured by hydroxyproline and pyridinoline content, respectively. Thirty days post-injury, the cellularity and the collagen matrix approached a normal tendon. The ultimate stress of the healing tendon restored to an average of 71% of the control and remained constant over time. The pyridinoline of the healing tendon was twice the values for the controls by 30 days and then reached a plateau. However, the hydroxyproline did not change significantly over time. Stepwise regression analysis demonstrated that pyridinoline was a better biochemical marker for the ultimate stress than hydroxyproline. The current study provides insights into the healing process in tendon by establishing the relationship between the biochemical parameters with the ultimate stress. This study also suggests the possibility of using pyridinoline content as an indirect marker of the ultimate stress, since in vivo clinical assessment is impossible.
著者Chan BP, Fu SC, Qin L, Chan KM
會議名稱10th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
會議開始日29.10.1998
會議完結日01.11.1998
會議地點HONG KONG
會議國家/地區中國
期刊名稱PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6
出版年份1998
月份1
日期1
卷號20
出版社IEEE
頁次2471 - 2473
國際標準書號0-7803-5164-9
國際標準期刊號1094-687X
語言英式英語
關鍵詞healing; patellar tendon; pyridinoline; ultimate stress
Web of Science 學科類別Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; Clinical Neurology; Engineering; Engineering, Biomedical; Medical Informatics; Medical Laboratory Technology; Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging

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