An in vivo study of the rat patellar tendon healing - Histological, biochemical and biomechanical aspects
Refereed conference paper presented and published in conference proceedings


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AbstractPatellar tendon central one third is removed during anterior cruciate ligament reconstruction. The current study investigates an in vivo model of patellar tendon healing, histologically, biochemically and biomechanically. The histological appearance and the ultimate stress of the central one third patellar tendon were studied over time. The specimens were also analyzed for collagen and non-reducible crosslinks, as measured by hydroxyproline and pyridinoline content, respectively. Thirty days post-injury, the cellularity and the collagen matrix approached a normal tendon. The ultimate stress of the healing tendon restored to an average of 71% of the control and remained constant over time. The pyridinoline of the healing tendon was twice the values for the controls by 30 days and then reached a plateau. However, the hydroxyproline did not change significantly over time. Stepwise regression analysis demonstrated that pyridinoline was a better biochemical marker for the ultimate stress than hydroxyproline. The current study provides insights into the healing process in tendon by establishing the relationship between the biochemical parameters with the ultimate stress. This study also suggests the possibility of using pyridinoline content as an indirect marker of the ultimate stress, since in vivo clinical assessment is impossible.
All Author(s) ListChan BP, Fu SC, Qin L, Chan KM
Name of Conference10th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
Start Date of Conference29/10/1998
End Date of Conference01/11/1998
Place of ConferenceHONG KONG
Country/Region of ConferenceChina
Journal namePROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6
Year1998
Month1
Day1
Volume Number20
PublisherIEEE
Pages2471 - 2473
ISBN0-7803-5164-9
ISSN1094-687X
LanguagesEnglish-United Kingdom
Keywordshealing; patellar tendon; pyridinoline; ultimate stress
Web of Science Subject CategoriesCardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; Clinical Neurology; Engineering; Engineering, Biomedical; Medical Informatics; Medical Laboratory Technology; Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging

Last updated on 2021-18-09 at 00:37