Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart
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摘要A novel human fibroblast growth factor (hFGF), which shows 75% sequence homology with fibroblast growth factor-9, was isolated in random sequencing of a human heart cDNA library. The full-length sequence is 928 bp, the encoded protein is composed of 168 amino acid residues, and its pi value and molecular weight were estimated to be 8.13 and 19.1 kDa, respectively. RT-PCR using Marathon human heart cDNA shows that the coding region is approximately 507 bp. Southern hybridization showed a single band which indicates that this is a single copy gene. Northern hybridization done on a human multiple tissues blot showed that the gene is preferentially expressed in human heart, very weakly detectable in human brain and not detectable in 18 other different human tissues. (C) 1999 Academic Press.
著者Kok LDS, Tsui SKW, Waye M, Liew CC, Lee CY, Fung KP
期刊名稱Biochemical and Biophysical Research Communications
出版年份1999
月份2
日期24
卷號255
期次3
出版社ACADEMIC PRESS INC
頁次717 - 721
國際標準期刊號0006-291X
電子國際標準期刊號1090-2104
語言英式英語
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS

上次更新時間 2020-12-08 於 00:45