Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides
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AbstractThe immunomodulating action of two mushroom antitumor polysaccharides, polysaccharide-protein complex (PSPC) and lentinan, was elucidated through analysing the expression profile of cytokines during a time course (0 h to 48 h) after their administration. Among the 5 cytokine genes, the induction of a marked increase in the mRNA levels of IL-1 alpha, IL-1 beta, TNF-alpha, IFN-gamma and M-CSF by PSPC and lentinan was observed in the peritoneal exudate cells and splenocytes. However, the time point of their increased production was different after PSPC and lentinan administration.
All Author(s) ListLiu F, Ooi VEC, Fung MC
Journal nameLife Sciences
Volume Number64
Issue Number12
Pages1005 - 1011
LanguagesEnglish-United Kingdom
Keywordscytokine; immunomodulation; mushroom; polysaccharide; splenocyte
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

Last updated on 2021-29-07 at 01:05