Serotonin-independent model of cisplatin-induced emesis in the ferret
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要para-Chlorophenylalanine (PCPA, 100-200 mg/kg) was used as a pharmacological tool to characterize the 5-hydroxytryptamine (5-HT) involvement in the emesis occurring 24 hr after the administration of cisplatin (10 mg/kg) in the ferret. PCPA was effective to antagonize the initial 8 hr period of retching and vomiting, but potentiated the emesis that occurred during the remaining 8- to 24-hr observation period. Tissue samples removed from the brainstem at 24 hr post injection of cisplatin alone revealed an elevation of 5-HT, dopamine and homovanillic acid that was antagonized by the injection of PCPA. Cisplatin also induced increases in the urinary levels of 5-hydroxyindoleacetic acid that was similarly antagonized by PCPA. Results are discussed in terms of the relevance of 5-HT to the model of cisplatin (10 mg/kg)-induced emesis in the ferret compared to the problem of acute and delayed emesis in man. The residual or delayed phase of cisplatin-induced emesis may involve a 5-HT-independent mechanism.
著者Rudd JA, Cheng CHK, Naylor RJ
期刊名稱Japanese Journal of Pharmacology
出版年份1998
月份11
日期1
卷號78
期次3
出版社JAPANESE PHARMACOLOGICAL SOC
頁次253 - 260
國際標準期刊號0021-5198
語言英式英語
關鍵詞cisplatin; delayed; emesis; ferret; p-chlorophenylalanine
Web of Science 學科類別Pharmacology & Pharmacy

上次更新時間 2020-24-10 於 03:31