Characterization of a prostanoid EP3-receptor in guinea-pig aorta: partial agonist action of the non-prostanoid ONO-AP-324
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摘要1 Contraction of guinea-pig isolated aorta induced by the prostaglandin E analogue sulprostone (1-400 nM) has a lower maximum response (40%) than that of phenylephrine or U-46619 (TP-receptor agonist). A prostanoid EP3-receptor subtype is involved based on agonist potency ranking: equi-effective molar ratios (EMR) are sulprostone (EC(50)similar to 23 nM) 1.0, SC-46275 0.11, misoprostol 2.2, gemeprost 3.3, PGE(2) 5.4, 17-phenyl PGE(2) 6.0, GR-63799 8.9. GR-63799, which contains a bulky ester group, is relatively more potent on neuronal EP3 preparations than on the aorta.
著者Jones RL, Qian YM, Chan KM, Yim APC
期刊名稱British Journal of Pharmacology
出版年份1998
月份11
日期1
卷號125
期次6
出版社STOCKTON PRESS
頁次1288 - 1296
國際標準期刊號0007-1188
電子國際標準期刊號1476-5381
語言英式英語
關鍵詞arterial smooth muscle; G(i)-coupled second messenger systems; L-type Ca2+-channel blockers; non-prostanoid EP3 agonists; non-prostanoid prostacyclin mimetics; prostaglandin E-2; prostanoid EP3-receptors; sulprostone
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-24-10 於 03:30