Pyridinoline in relation to ultimate stress of the patellar tendon during healing: An animal study
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摘要The ultimate stress of the central one-third of the patellar tendon was studied in a gap wound-healing model in the rat. The specimens were also analyzed for collagen and nonreducible crosslinks, as measured by hydroxyproline and pyridinoline content, respectively. Thirty days after injury, the ultimate stress of the healing patellar tendon was restored to an average of 71% of the control value and remained constant over time. The pyridinoline content of the healing tendon was twice the control value by 30 days after injury and reached a plateau; however, the hydroxyproline content did not change significantly over time. Stepwise regression analysis demonstrated that pyridinoline was a better biochemical marker for ultimate stress than was hydroxyproline. The current study provides insights into the functional behaviour of the healing patellar tendon by establishing the relationship between the two biochemical components and the ultimate stress of the healing patellar tendon. This study also suggests the possibility of using pyridinoline content as an indirect marker of the ultimate stress because in vivo assessment is impossible.
著者Chan BP, Fu SC, Qin L, Rolf C, Chan KM
期刊名稱Journal of Orthopaedic Research
出版年份1998
月份9
日期1
卷號16
期次5
出版社JOURNAL BONE JOINT SURGERY INC
頁次597 - 603
國際標準期刊號0736-0266
電子國際標準期刊號1554-527X
語言英式英語
Web of Science 學科類別Orthopedics; ORTHOPEDICS

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