5-HT3 receptors are not involved in conditioned taste aversions induced by 5-hydroxytryptamine, ipecacuanha or cisplatin
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要We have used the rat to examine the involvement of the 5-HT3 receptor in the mechanism(s) of conditioned taste aversion induced by 5-hydroxytryptamine (5-HT) and selected emetic drugs. 5-HT, ipecacuanha and cisplatin all induced conditioned taste aversion at doses known to induce emesis in other species but the responses were resistant to treatment with the 5-HT3 receptor antagonists ondansetron and granisetron. Further, m-chlorophenylbiguanide, a selective and potent 5-HT3 receptor agonist, failed to induce a conditioned taste aversion. The data provide strong evidence that the 5-HT3 receptor is not involved in conditioned taste aversion mechanisms in the rat. Results are discussed in terms of the usefulness of the rat conditioned taste aversion paradigm to anti-emetic research. (C) 1998 Elsevier Science B.V. All rights reserved.
著者Rudd JA, Ngan MP, Wai MK
期刊名稱European Journal of Pharmacology
出版年份1998
月份7
日期10
卷號352
期次2-3
出版社ELSEVIER SCIENCE BV
頁次143 - 149
國際標準期刊號0014-2999
電子國際標準期刊號1879-0712
語言英式英語
關鍵詞(rat); 5-HT3 receptor; conditioned taste aversion
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-14-09 於 02:45