Occlusion of the presynaptic action of cannabinoids in rat substantia nigra pars reticulata by cadmium
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摘要Whole-cell patch-clamp recordings were made from substantia nigra pars reticulata (SNR) neurones in rat midbrain slices to characterise the presynaptic action of cannabinoids on GABA neurotransmission and to study the involvement of calcium channels. The cannabinoid agonist WIN55212-2 at 10 mu M reduced the amplitudes of GABA(A) receptor mediated spontaneous postsynaptic currents (IPSCs). This effect was fully reversed by the selective cannabinoid CB1 receptor antagonist SR141716A (20 mu M) WIN55212-2 also caused a reduction in the evoked IPSC amplitude, which was associated with a significant increase in the paired pulse ratio over a 50 ms interval. In addition, the reduction in spontaneous IPSC amplitude by WIN55212-2 could be largely occluded by the presence of extracellular Cd2+ (200 mu M). These observations suggest that cannabinoids exert a presynaptic inhibition on GABAergic transmission to SNR neurones via CB1 receptor, an action which involves inhibition of Cd2+-sensitive presynaptic Ca2+ channels. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.
著者Chan PKY, Yung WH
期刊名稱Neuroscience Letters
出版年份1998
月份6
日期12
卷號249
期次1
出版社ELSEVIER SCI IRELAND LTD
頁次57 - 60
國際標準期刊號0304-3940
電子國際標準期刊號1872-7972
語言英式英語
關鍵詞Ca2+ channels; cadmium; cannabinoids; SR141716A; substantia nigra pars reticulata
Web of Science 學科類別Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

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