Differential expression of pre- and postsynaptic GABA(B) receptors in rat substantia nigra pars reticulata neurones
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摘要Whole-cell recordings were made from substantia nigra pars reticulata in rat midbrain slices to study the functional expression of pre- and postsynaptic GABA(B) receptors in GABA output neurones. Baclofen (up to 300 mu M) dose-dependently activated a weak current which was insensitive to tetrodotoxin and Ca2+-free solution but blocked by Ba2+ and 2-OH-saclofen. The maximum current activated by baclofen (30 mu M) was 43.0 +/- 4.5 pA (n = 27), representing only 23% of that in dopamine neurones. Baclofen (1-30 mu M) also reduced the frequency of the GABA(A) receptor-mediated miniature inhibitory postsynaptic currents while the distribution of their amplitudes was unaffected. This presynaptic effect of baclofen, prominent at a concentration as low as 1 mu M, was sensitive to 2-OH-saclofen and occluded by Cd2+, but was unaffected by Ba2+. The results suggest a predominant role of the presynaptic GABA(B) receptors in substantia nigra pars reticulata. The relative abundance of pre- and postsynaptic GABA(B) receptor subtypes in this brain region may also be important in mediating the anticonvulsant effect of baclofen in rats. (C) 1998 Elsevier Science B.V. All rights reserved.
著者Chan PKY, Leung CKS, Yung WH
期刊名稱European Journal of Pharmacology
出版年份1998
月份5
日期22
卷號349
期次2-3
出版社ELSEVIER SCIENCE BV
頁次187 - 197
國際標準期刊號0014-2999
電子國際標準期刊號1879-0712
語言英式英語
關鍵詞baclofen; GABA(B) receptor; substantia nigra
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

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