A novel lectin with potent immunomodulatory activity isolated from both fruiting bodies and cultured mycelia of the edible mushroom Volvariella volvacea
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AbstractA novel lectin has been purified from the fruiting bodies as well as cultured mycelia of the edible mushroom Volvariella voluacea. The lectin, designated as VVL, was a homodimeric protein with a molecular weight of 32 kDa as demonstrated by gel filtration and SDS-PAGE. VVL had no carbohydrate moiety, and its hemagglutinating activity was inhibited by thyroglobulin but not by simple carbohydrates such as monomeric or dimeric sugars. The immunomodulatory activity of VVL was demonstrated by its potent stimulatory activity toward murine splenic lymphocytes, VVL was also found to markedly enhance the transcriptional expression of interleukin-2 and interferon-gamma by reverse transcriptase-polymerase chain reaction. As revealed by its N-terminal amino acid sequence, VVL possessed a molecular structure distinct from other immunomodulatory proteins previously reported in the same fungus. (C) 1998 Academic Press.
All Author(s) ListShe QB, Ng TB, Liu WK
Journal nameBiochemical and Biophysical Research Communications
Year1998
Month6
Day9
Volume Number247
Issue Number1
PublisherACADEMIC PRESS INC
Pages106 - 111
ISSN0006-291X
eISSN1090-2104
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS

Last updated on 2020-03-06 at 23:25