Differential localization of GABA(A) receptor alpha and beta subunits in the hamster retina and relationship with glutamic acid decarboxylase immunoreactivity
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AbstractIn order to determine the cellular localization of GABA(A) alpha and beta subunits in the hamster retina, single and double immunocytochemistry was performed in perfuse-fixed hamster retina using commercially-available antibodies against the two receptor subunits and glutamic acid decarboxylase. Strong GABA(A) beta immunoreactivity was found in two strata of the inner plexiform layer and in perikarya of amacrine cells and bipolar cells in the inner nuclear layer. In contrast, no GABA(A) alpha immunoreactivity was detected. All but a few of the GABA(A) beta-immunoreactive amacrine cells were found not to display glutamic acid decarboxylase immunoreactivity. The present results indicate that there is a differential localization of GABA(A) alpha and beta subunits in different neuronal subpopulations in the hamster retina. (C) 1998 Elsevier Science Ireland Ltd.
All Author(s) ListLee YL, Cho EYP, Yung KKL
Journal nameNeuroscience Letters
Volume Number248
Issue Number1
Pages29 - 32
LanguagesEnglish-United Kingdom
Keywordsavidin-biotin-peroxidase reaction; GABA(A)alpha subunit; GABA(A)beta subunit; immunocytochemistry; immunofluorescence
Web of Science Subject CategoriesNeurosciences; NEUROSCIENCES; Neurosciences & Neurology

Last updated on 2020-07-07 at 02:31