Apoptosis in astrocytomas with different grades of malignancy
Publication in refereed journal

香港中文大學研究人員

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摘要Apoptosis, a form of programmed cell death was studied in astrocytomas with varying stages of malignancy, including low grade astrocytoma, anaplastic astrocytoma and glioblastoma multiforme. Apoptosis was visualized by employing the TUNEL technique and the evaluation of nuclear morphology and this was correlated with a study of bcl 2 expression. A decrease in the percentage of apoptotic cells and bcl 2 expression were evident with increasing malignancy. Furthermore, there was an increase in the proportion of apoptotic cells of the early stage in the more advanced form of astrocytoma. This is a study which demonstrates a possible direct inverse relationship between the severity of apoptosis and the stages of malignancy.
著者Yew DT, Wang HH, Zheng DR
期刊名稱Acta Neurochirurgica
出版年份1998
月份1
日期1
卷號140
期次4
出版社SPRINGER-VERLAG WIEN
頁次341 - 347
國際標準期刊號0001-6268
語言英式英語
關鍵詞apoptosis; astrocytoma; blc 2; human; TUNEL
Web of Science 學科類別Clinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology; Surgery; SURGERY

上次更新時間 2020-20-09 於 02:12