Apoptosis in astrocytomas with different grades of malignancy
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AbstractApoptosis, a form of programmed cell death was studied in astrocytomas with varying stages of malignancy, including low grade astrocytoma, anaplastic astrocytoma and glioblastoma multiforme. Apoptosis was visualized by employing the TUNEL technique and the evaluation of nuclear morphology and this was correlated with a study of bcl 2 expression. A decrease in the percentage of apoptotic cells and bcl 2 expression were evident with increasing malignancy. Furthermore, there was an increase in the proportion of apoptotic cells of the early stage in the more advanced form of astrocytoma. This is a study which demonstrates a possible direct inverse relationship between the severity of apoptosis and the stages of malignancy.
All Author(s) ListYew DT, Wang HH, Zheng DR
Journal nameActa Neurochirurgica
Volume Number140
Issue Number4
Pages341 - 347
LanguagesEnglish-United Kingdom
Keywordsapoptosis; astrocytoma; blc 2; human; TUNEL
Web of Science Subject CategoriesClinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology; Surgery; SURGERY

Last updated on 2020-03-06 at 01:21