The Hering-Breuer reflex in anesthetized infants: end-inspiratory vs. end-expiratory occlusion technique
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香港中文大學研究人員

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摘要Both end-inspiratory (EIO) and end-expiratory (EEO) occlusions have been used to measure the strength of the Hering-Breuer inflation reflex (HBIR) in infants. The purpose of this study was to compare both techniques in anesthetized infants. In each infant, HBIR activity was calculated as the relative prolongation of expiratory and inspiratory time during EIO and EEO, respectively. Respiratory drive was assessed from the change in airway pressure during inspiratory effort against the occlusion, both at a fixed time interval of 100 ms (P-0.1) and a fixed proportion (10%) of the occluded inspiratory time (P-10%). Twenty-two infants [age 14.3 +/- 6.4 (SD) mo] were studied. No HBIR activity was present during EIO [-11.8 +/- 15.9 (SD) %]. By contrast, there was significant, albeit weak, reflex activity during EEO [HBIR: 27.2 +/- 17.4%]. A strong HBIR (up to 310%) was elicited in six of seven infants in whom EIO was repeated after lung inflation. P-0.1 was similar during both types of occlusions, whereas mean +/- SD P-10% was lower during EEO than during EIO: 0.198 +/- 0.09 vs. 0.367 +/- 0.15 kPa, respectively (P < 0.01). These data suggest a difference in the central integration of stretch receptor activity in infants during anesthesia compared with during sleep.
著者Brown K, Stocks J, Aun C, Rabbette PS
期刊名稱Journal of Applied Physiology
出版年份1998
月份4
日期1
卷號84
期次4
出版社AMER PHYSIOLOGICAL SOC
頁次1437 - 1446
國際標準期刊號8750-7587
語言英式英語
關鍵詞anesthesia; control of breathing; halothane; healthy infants; Hering-Breuer inflation reflex; respiratory drive; sevoflurane
Web of Science 學科類別Physiology; PHYSIOLOGY; Sport Sciences; SPORT SCIENCES

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