CFTR gene and male fertility
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AbstractSecretion of electrolytes and water by the epididymal epithelium is important in the formation an optimal fluid environment for sperm maturation and transport. This process is disrupted in the genetic disease cystic fibrosis caused by mutation of the cystic fibrosis transmemebrane conductance regulator (CFTR) gene. Recent findings of CFTR gene mutations in healthy men with congenital bilateral absence of the vas deferens or poor sperm quality may indicate that CFTR gene mutations have a far-reaching effect on human reproduction.
All Author(s) ListWong PYD
Journal nameMolecular Human Reproduction
Volume Number4
Issue Number2
Pages107 - 110
LanguagesEnglish-United Kingdom
KeywordsCBAVD; CFTR; chloride secretion; cystic fibrosis; epididymis
Web of Science Subject CategoriesDevelopmental Biology; DEVELOPMENTAL BIOLOGY; Obstetrics & Gynecology; Reproductive Biology; REPRODUCTIVE BIOLOGY

Last updated on 2020-30-05 at 00:03