Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要WHOLE-CELL patch-clamp recordings were made from substantia nigra pars reticulata (SNR) neurones in rat midbrain slices to investigate the electrophysiological effects of cannabinoids. The cannabinoid receptor agonist WIN 55212-2 (10 mu M) significantly reduced intranigrally evoked and spontaneous inhibitory postsynaptic currents (IPSCs) which were mediated by GABA(A) receptors. The postsynaptic current induced by bath application of GABA was not affected by the presence of WIN 55212-2. The actions of WIN 55212-2 were not mimicked by the inactive enantiomer WIN 55212-3. WIN 55212-2 also hyperpolarized the membrane of SNR neurones in a tetrodotoxin/0-Ca2+-insensitive manner. These data suggest that cannabinoids modulate the activity of SNR neurones by presynaptic inhibition of GABA inputs. They may also exert a direct post-synaptic inhibition on these neurones.
著者Chan PKY, Chan SCY, Yung WH
期刊名稱NeuroReport
出版年份1998
月份3
日期9
卷號9
期次4
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次671 - 675
國際標準期刊號0959-4965
電子國際標準期刊號1473-558X
語言英式英語
關鍵詞cannabinoid; GABA; IPSC; substantia nigra
Web of Science 學科類別Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

上次更新時間 2020-24-10 於 03:13