Immunohistochemical localization of angiotensin II in the mouse pancreas
Publication in refereed journal


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摘要Previous studies have suggested the presence of a tissue renin-angiotensin II system in the pancreas. These studies were based on the observation of several key components of the renin-angiotensin II system using molecular biological, biochemical and pharmacological approaches. In the present study, angiotensin II was localized immunohistochemically in the mouse pancreas using an indirect immunoperoxidase-staining technique. The results showed that angiotensin II-like immunoreactivity was localized predominantly in the endothelial cells of pancreatic blood vessels and the epithelial cells of pancreatic ducts from a subgroup of the vessels and ducts. Compared with those found in the pancreatic blood vessels and ductal system, a less pronounced immunoreactivity for angiotensin II was also observed in the acinar cells and in the smooth muscle layers overlying the pancreatic ducts as well as the blood vessels. However, no angiotensin II-like immunoreactivity was detected in the islet cells. Taken together with previous findings, the present results suggest a local angiotensin II-forming system in the mouse pancreas, which may be a significant autocrine or paracrine modulator of diverse pancreatic functions, including regulation of pancreatic blood flow and pancreatic anion secretion. (C) 1998 Chapman & Hall.
著者Leung PS, Chan HC, Wong PYD
期刊名稱Histochemical Journal
出版年份1998
月份1
日期1
卷號30
期次1
出版社KLUWER ACADEMIC PUBL
頁次21 - 25
國際標準期刊號0018-2214
語言英式英語
Web of Science 學科類別Cell Biology

上次更新時間 2021-21-02 於 23:49