Developmental regulation of 14-3-3 epsilon isoform in rat heart
Publication in refereed journal


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摘要Human heart cDNA sequencing yielded a cDNA clone that is similar in DNA and amino acid sequences to that of mouse 14-3-3 epsilon isoform. The 6xHis-tagged H1433 epsilon recombinant protein was expressed in Escherichia coli and its size was approximately 30 kDa. From Northern blot results with human multiple tissues, human skeletal muscle was found to have the highest level of hi 433 epsilon mRNA expression, whereas Northern blots of human cancer cell lines detected the highest mRNA level of h1433 epsilon in colorectal adenocarcinoma SW480. The protein expression level of h1433 epsilon and Raf-1 is found to be regulated coordinately during rat heart development, and their protein expression was highest from 14.5 to 16.5 days postcoitum. (C) 1998 Wiley-Liss, Inc.
著者Luk SCW, Ngai SM, Tsui SKW, Chan KK, Fung KP, Lee CY, Waye MMY
期刊名稱Journal of Cellular Biochemistry
出版年份1998
月份2
日期1
卷號68
期次2
出版社WILEY-LISS
頁次195 - 199
國際標準期刊號0730-2312
電子國際標準期刊號1097-4644
語言英式英語
關鍵詞14-3-3 protein; developmental regulation; heart development; Raf-1
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY

上次更新時間 2020-08-08 於 02:04