Developmental regulation of 14-3-3 epsilon isoform in rat heart
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AbstractHuman heart cDNA sequencing yielded a cDNA clone that is similar in DNA and amino acid sequences to that of mouse 14-3-3 epsilon isoform. The 6xHis-tagged H1433 epsilon recombinant protein was expressed in Escherichia coli and its size was approximately 30 kDa. From Northern blot results with human multiple tissues, human skeletal muscle was found to have the highest level of hi 433 epsilon mRNA expression, whereas Northern blots of human cancer cell lines detected the highest mRNA level of h1433 epsilon in colorectal adenocarcinoma SW480. The protein expression level of h1433 epsilon and Raf-1 is found to be regulated coordinately during rat heart development, and their protein expression was highest from 14.5 to 16.5 days postcoitum. (C) 1998 Wiley-Liss, Inc.
All Author(s) ListLuk SCW, Ngai SM, Tsui SKW, Chan KK, Fung KP, Lee CY, Waye MMY
Journal nameJournal of Cellular Biochemistry
Volume Number68
Issue Number2
Pages195 - 199
LanguagesEnglish-United Kingdom
Keywords14-3-3 protein; developmental regulation; heart development; Raf-1
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY

Last updated on 2020-07-07 at 02:28