Inhibition of rat peritoneal mast cell exocytosis by frusemide: A comparison with disodium cromoglycate
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AbstractAmong the loop diuretics, frusemide possesses unique airway protective activities which may be due to the inhibition of airway inflammatory cells such as the mast cell. We previously reported that frusemide and disodium cromoglycate (DSCG) demonstrated a similar profile of inhibitory activities against histamine release from rat peritoneal mast cells activated by various stimuli which increased intracellular calcium via different routes. Furthermore, the inhibitory activities of both compounds demonstrated marked tachyphylaxis and we hence postulated that frusemide and DSCG might share the same mechanism of action which involves the prevention of extracellular calcium influx into the mast cell cytoplasm. The present study confirmed the postulation by (a) demonstrating that cross-tachyphylaxis exists between the two compounds and (b) extending the observations on histamine release to the influx of extracellular calcium (Ca-45) into rat peritoneal mast cells. (C) 1997 Elsevier Science Inc.
All Author(s) ListStenton GR, Chow SM, Lau HYA
Journal nameLife Sciences
Volume Number62
Issue Number3
PagesPL49 - PL54
LanguagesEnglish-United Kingdom
Keywordsantiallergic compounds; asthma; calcium; disodium cromoglycate; frusemide; mast cells
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

Last updated on 2020-24-10 at 03:09