Engineering protein interfaces yields ferritin disassembly and reassembly under benign experimental conditions
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AbstractFerritin nanocages are promising platforms for drug encapsulation. However, extreme conditions (pH <= 2) required for dissociation limit their application. Here, we engineered protein interfaces to yield ferritin nanocages which disassemble at pH 4.0 and reassemble at pH 7.5. During this process, bioactive molecules can be encapsulated within the protein cavity.
All Author(s) ListChen H, Zhang S, Xu C, Zhao G
Journal nameChemical Communications
Year2016
Month1
Day1
Volume Number52
Issue Number46
PublisherROYAL SOC CHEMISTRY
Pages7402 - 7405
ISSN1359-7345
eISSN1364-548X
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesChemistry; Chemistry, Multidisciplinary

Last updated on 2020-03-07 at 01:26