Engineering protein interfaces yields ferritin disassembly and reassembly under benign experimental conditions
Publication in refereed journal

香港中文大學研究人員

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其它資訊
摘要Ferritin nanocages are promising platforms for drug encapsulation. However, extreme conditions (pH <= 2) required for dissociation limit their application. Here, we engineered protein interfaces to yield ferritin nanocages which disassemble at pH 4.0 and reassemble at pH 7.5. During this process, bioactive molecules can be encapsulated within the protein cavity.
著者Chen H, Zhang S, Xu C, Zhao G
期刊名稱Chemical Communications
出版年份2016
月份1
日期1
卷號52
期次46
出版社ROYAL SOC CHEMISTRY
頁次7402 - 7405
國際標準期刊號1359-7345
電子國際標準期刊號1364-548X
語言英式英語
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary

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